業績

Publication

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2024

• Sakumoto T, Narita T, Morito S, Nishiyama M, Hashiguchi M, Mine Y, Iwamoto S, Toda S, Aoki S
  Novel cell spheroid culture method using Medaka dried fish powder
  Heliyon, e3841 (2024) (in press). doi: 10.1016/j.heliyon.2024.e38418
• Nishiyama M, Sakaguchi Y, Morito S, Nagase K, Sakumoto T, Yamashita K, Hashiguchi M, Fukuda M, Toda S, Aoki S
  A new lymphedema treatment using pyro-drive jet injection.
  Human Cell 37, 465-477 (2024). doi: 10.1007/s13577-023-01021-2.

2023

• Morito S, Kawasaki M, Nishiyama M, Sakumoto T, Hashiguchi M, Narita T, Kawaguchi A, Toda S, Aoki S
  Microenvironmental elements singularity synergistically regulate the behavior and chemosensitivity of endometrioid carcinoma.
  Human Cell 36, 1147-1159 (2023). doi: 10.1007/s13577-023-00886-7.
• Iwamoto S, Nishiyama M, Kawasaki M, Morito S, Sakumoto T, Toda S, Yamashita Y, Aoki S.
  Oral-specific microenvironments regulate cell behavior and anticancer drug sensitivity of tongue squamous cell carcinoma.
  Human Cell 36, 643-656 (2023). doi: 10.1007/s13577-023-00866-x.
• Maruo K, Nishiyama M, Honda Y, Cao AL, Gao WQ , Shibata K, Murata Y, Kido MA
  Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats.
  Arch Oral Biol. 2023 Feb;146:105601. doi: 10.1016/j.archoralbio.2022.105601.

2022

• Iwamoto Y, Haraguchi R, Nakao R, Aoki S, Oishi Y, Narita T
  One-Pot Preparation of Collagen Tubes Using Diffusing Gelation.
  ACS Omega. 2022;7;22872-22878. doi: 10.1021/acsomega.2c02623.
• Aoki S, Higashimoto K, Hidaka H, Ohtsuka Y, Aoki S, Mishima H, Yoshiura K, Nakabayashi K, Hata K, Yatsuki H, Hara S, Ohba T, Katabuchi H, Soejima H
  Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia.
  Clinical Epigenetics. 2022;14(1):64. doi: 10.1186/s13148-022-01280-0.
• Danjo A, Aijima R, Yoshimoto RU, Tanaka S, Iwamoto S, Katsuki T, Aoki S, Kido MA, Yamashita Y
  An ultrasonic osteotomy device enhanced post-osteotomy bone healing beyond that with a conventional rotary device in a rat calvarial model.
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2022;34:243-251.
• Kawasaki M, Nagase K, Aoki S, Udo K, Tobu S, Rikitake-Yamamoto M, Kubota M, Narita T,Noguchi M
  Bystander effects induced by the interaction between urothelial cancer cells and irradiated adipose tissue-derived stromal cells in urothelial carcinoma.
  Human Cell.2022 Jan 19. doi: 10.1007/s13577-022-00668-7.

2021

• Hanashima K, Akutagawa T, Rikitake-Yamamoto M, Sakumoto T, Futamata M, Nakao Y, Yokoyama M, Toda S, Aoki S
  Tissue-specific physical and biological microenvironments modulate the behavior of cervical squamous cell carcinoma.
  Acta Histochemica et Cytochemica. 2021;54(5):155-65
• Yamaguchi J, Moriuchi H, Ueda T, Kawashita Y, Hazeyama T, Tateishi M, et al.
  Active behavior of triple-negative breast cancer with adipose tissue invasion: a single center and retrospective review.
  BMC cancer. 2021;21(1):1-11.
• Nagase K, Akutagawa T, Rikitake-Yamamoto M, Morito S, Futamata M, Tobu S, et al.
  Cellular and physical microenvironments regulate the aggressiveness and sunitinib chemosensitivity of clear cell renal cell carcinoma.
  The Journal of Pathology. 2021.
• Hashiguchi M, Takezawa T, Nagase K, Tayama-Abe M, Matsuhisa F, Kitajima S, et al.
  Collagen vitrigel membrane-coated nylon line prevents stenosis after conization of the cervix uteri.
  Tissue Engineering. 2021(ja).

2020

• Tao F, Sayo K, Sugimoto K, Aoki S, Kojima N.
  Development of a tunable method to generate various three-dimensional microstructures by replenishing macromolecules such as extracellular matrix components and polysaccharides.
  Scientific reports. 2020;10(1):1-12.

2019

• Kawata K, Aoki S, Futamata M, Yamamoto-Rikitake M, Nakao I, Enaida H, et al.
  Mesenchymal cells and fluid flow stimulation synergistically regulate the kinetics of corneal epithelial cells at the air-liquid interface.
  Graefes Arch Clin Exp Ophthalmol. 2019;257(9):1915-24.
• Aoki S, Takezawa T, Nagase K, Oshikata-Mitazaki A, Morito S, Sakumoto T, et al.
  A high-density collagen xerogel thread prevents the progression of peritoneal fibrosis.
  Biomaterials science. 2019;7(1):125-38.

2018

• Aoki S, Takezawa T, Nagase K, Oshikata-Mitazaki A, Morito S, Sakumoto T, et al.
  A high-density collagen xerogel thread prevents the progression of peritoneal fibrosis.
  Biomater Sci. 2018;7(1):125-38.
• Akutagawa T, Aoki S, Yamamoto-Rikitake M, Iwakiri R, Fujimoto K, Toda S.
  Cancer-adipose tissue interaction and fluid flow synergistically modulate cell kinetics, HER2 expression, and trastuzumab efficacy in gastric cancer.
  Gastric Cancer. 2018;21(6):946-55.

2017

• Maruki H, Sato M, Takezawa T, Tani Y, Yokoyama M, Takahashi T, et al.
  Effects of a cell-free method using collagen vitrigel incorporating TGF-beta1 on articular cartilage repair in a rabbit osteochondral defect model.
  J Biomed Mater Res B Appl Biomater. 2017;105(8):2592-602.
• Aoki S, Sakata Y, Shimoda R, Takezawa T, Oshikata-Miyazaki A, Kimura H, et al.
  High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model.
  Gastrointest Endosc. 2017;85(5):1076-85.

2016

• Yamamoto M, Uchihashi K, Aoki S, Koike E, Kakihara N, Toda S.
  Interaction between thyrocytes and adipose tissue in vitro.
  Pathol Int. 2016;66(3):148-57.
• Sayo K, Aoki S, Kojima N.
  Fabrication of bone marrow-like tissue in vitro from dispersed-state bone marrow cells.
  Regen Ther. 2016;3:32-7.
• Rumbajan JM, Yamaguchi Y, Nakabayashi K, Higashimoto K, Yatsuki H, Nishioka K, et al.
  The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants.
  Gene. 2016;583(2):141-6.
• Nakayama A, Aoki S, Uchihashi K, Nishijima-Matsunobu A, Yamamoto M, Kakihara N, et al.
  Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro.
  Am J Pathol. 2016;186(5):1180-94.
• Motoyama W, Sayo K, Mihara H, Aoki S, Kojima N.
  Induction of hepatic tissues in multicellular spheroids composed of murine fetal hepatic cells and embedded hydrogel beads.
  Regenerative Therapy. 2016;3:7-10.
• Kawasaki-Nanri M, Aoki S, Uchihashi K, Yamamoto M, Udo K, Nishijima-Matsunobu A, et al.
  Differential effects of adipose tissue stromal cells on the apoptosis, growth and invasion of bladder urothelial carcinoma between the superficial and invasive types.
  Int J Urol. 2016;23(6):510-9.
• Kawano H, Inoue K, Matsumoto Y, Sato O, Arakawa S, Nakatomi D, et al.
  Calcification around the struts of a sirolimus-eluting stent approximately 16 months after implantation in an autopsy case.
  Internal Medicine. 2016;55(4):353-8.
• Kai K, Aishima S, Aoki S, Takase Y, Uchihashi K, Masuda M, et al.
  Cytokeratin immunohistochemistry improves interobserver variability between unskilled pathologists in the evaluation of tumor budding in T1 colorectal cancer.
  Pathol Int. 2016;66(2):75-82.
• Aoki S, Takezawa T, Sugihara H, Toda S.
  Progress in cell culture systems for pathological research.
  Pathol Int. 2016;66(10):554-62.
• Aoki S, Noguchi M, Takezawa T, Ikeda S, Uchihashi K, Kuroyama H, et al.
  Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro.
  J Artif Organs. 2016;19(1):87-96.

2015

• Shimazu R, Aoki S, Kuratomi Y.
  Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.
  Auris Nasus Larynx. 2015;42(5):382-4.
• Koba S, Nagase K, Ikeda S, Aoki S, Misago N, Narisawa Y.
  Merkel cell carcinoma with glandular differentiation admixed with sweat gland carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from hair follicle stem cells.
  Am J Dermatopathol. 2015;37(3):e31-6.
• Aoki S, Takezawa T, Ikeda S, Narisawa Y, Oshikata-Miyazaki A, Miyauchi S, et al.
  A new cell-free bandage-type artificial skin for cutaneous wounds.
  Wound Repair Regen. 2015;23(6):819-29.

2014

• Uchihashi K, Tsuruta T, Mine H, Aoki S, Nishijima-Matsunobu A, Yamamoto M, et al.
  Histopathology of tenosynovium in trigger fingers.
  Pathol Int. 2014;64(6):276-82.
• Takashima T, Onozawa K, Rikitake S, Kishi T, Miyazono M, Aoki S, et al.
  Two cases of minor glomerular abnormalities with proteinuria disproportionate to the degree of hypoproteinemia.
  CEN Case Rep. 2014;3(2):172-7.
• Shimazu R, Kuratomi Y, Aoki S, Inokuchi A.
  Laryngeal granuloma in experimental rats with gastroesophageal reflux disease and mechanically injured vocal cord mucosa.
  Ann Otol Rhinol Laryngol. 2014;123(4):247-51.
• Murakami H, Okamura K, Aoki S, Sakagami R, Yamazaki J.
  Association of caspase‐14 and filaggrin expression with keratinization of the oral mucosa and reconstruction culture rat models.
  Journal of periodontal research. 2014;49(6):703-10.
• Koba S, Misago N, Nagase K, Tsuruta N, Inoue T, Ikeda S, et al.
  Triphasic differentiations of Merkel cell carcinoma in primary and metastatic lesions.
  J Cutan Pathol. 2014;41(5):469-74.
• Aoki S, Takezawa T, Miyazaki-Oshikata A, Ikeda S, Nagase K, Koba S, et al.
  Collagen vitrigel membrane: a powerful tool for skin regeneration.
  Inflammation and Regeneration. 2014;34(3):117-23.

2013

• Uchihashi K, Nishijima-Matsunobu A, Matsuyama A, Yamasaki F, Tanabe T, Uemura T, et al.
  Phosphaturic mesenchymal tumor, nonphosphaturic variant, causing fatal pulmonary metastasis.
  Hum Pathol. 2013;44(11):2614-8.
• Uchihashi K, Aoki S, Matsunobu A, Toda S.
  Osteoblast migration into type I collagen gel and differentiation to osteocyte-like cells within a self-produced mineralized matrix: a novel system for analyzing differentiation from osteoblast to osteocyte.
  Bone. 2013;52(1):102-10.
• Takahara K, Kakinoki H, Ikoma S, Udo K, Tobu S, Satoh Y, et al.
  Suture Granuloma Showing False-Positive Findings on FDG-PET.
  Case Rep Urol. 2013;2013:472642.
• Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, et al.
  Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma.
  BMC cancer. 2013;13(1):608.
• Nishijima-Matsunobu A, Aoki S, Uchihashi K, Fujimoto K, Toda S.
  Three-dimensional culture model for analyzing crosstalk between adipose tissue and hepatocytes.
  Cell Tissue Res. 2013;352(3):611-21.
• Koba S, Okawa T, Misago N, Yokoyama A, Aoki Y, Aoki S, et al.
  A case of tuberculous cellulitis lacking epithelioid granuloma.
  Acta Derm Venereol. 2013;93(5):596-7.
• Kishi T, Ikeda Y, Takashima T, Rikitake S, Miyazono M, Aoki S, et al.
  Acute renal failure associated with acute non-fulminant hepatitis B.
  World J Hepatol. 2013;5(2):82-5.
• Aoki S, Udo K, Morimoto H, Ikeda S, Takezawa T, Uchihashi K, et al.
  Adipose tissue behavior is distinctly regulated by neighboring cells and fluid flow stress: a possible role of adipose tissue in peritoneal fibrosis.
  J Artif Organs. 2013;16(3):322-31.

2012

• Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, et al.
  Periostin promotes chronic allergic inflammation in response to Th2 cytokines.
  The Journal of clinical investigation. 2012;122(7):2590-600.

2011

• Toda S, Aoki S, Uchihashi K, Matsunobu A, Yamamoto M, Ootani A, et al.
  Culture models for studying thyroid biology and disorders.
  ISRN Endocrinol. 2011;2011:275782.
• Taniguchi K, Yamamoto S, Aoki S, Toda S, Izuhara K, Hamasaki Y.
  Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.
  Exp Lung Res. 2011;37(8):461-70.
• Tada Y, Kondo S, Aoki S, Koarada S, Inoue H, Suematsu R, et al.
  Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.
  Arthritis Rheum. 2011;63(3):738-48.
• Ohtsuka Y, Kanaji T, Nishi M, Sakai N, Sato T, Aoki S, et al.
  A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis.
  Clin Nephrol. 2011;75(3):255-62.
• Nomoto-Kojima N, Aoki S, Uchihashi K, Matsunobu A, Koike E, Ootani A, et al.
  Interaction between adipose tissue stromal cells and gastric cancer cells in vitro.
  Cell Tissue Res. 2011;344(2):287-98.
• Misago N, Shinoda Y, Okawa T, Aoki S, Toda S, Koike K, et al.
  Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast?
  Clin Exp Dermatol. 2011;36(8):874-7.
• Kishi T, Ikeda Y, Miyazono M, Fukushima N, Aoki S, Sanai T, et al.
  A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation.
  NDT Plus. 2011;4(5):307-9.
• Aoki S, Makino J, Nagashima A, Takezawa T, Nomoto N, Uchihashi K, et al.
  Fluid flow stress affects peritoneal cell kinetics: possible pathogenesis of peritoneal fibrosis.
  Perit Dial Int. 2011;31(4):466-76.
• Aoki S, Ikeda S, Takezawa T, Kishi T, Makino J, Uchihashi K, et al.
  Prolonged effect of fluid flow stress on the proliferative activity of mesothelial cells after abrupt discontinuation of fluid streaming.
  Biochem Biophys Res Commun. 2011;416(3-4):391-6.
• Anan M, Uchihashi K, Aoki S, Matsunobu A, Ootani A, Node K, et al.
  A promising culture model for analyzing the interaction between adipose tissue and cardiomyocytes.
  Endocrinology. 2011;152(4):1599-605.

2010

• Yee CH, Aoki S, Uchihashi K, Matsunobu A, Yamasaki F, Misago N, et al.
  The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase.
  Acta Histochem Cytochem. 2010;43(1):1-7.
• Udo K, Aoki S, Uchihashi K, Kawasaki M, Matsunobu A, Tokuda Y, et al.
  Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture.
  Kidney Int. 2010;78(1):60-8.
• Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda E, Soejima H, et al.
  Organotypic culture of human bone marrow adipose tissue.
  Pathol Int. 2010;60(4):259-67.

2009

• Toda S, Uchihashi K, Aoki S, Sonoda E, Yamasaki F, Piao M, et al.
  Adipose tissue-organotypic culture system as a promising model for studying adipose tissue biology and regeneration.
  Organogenesis. 2009;5(2):50-6.
• Nagase K, Aoki S, Uchihashi K, Misago N, Shimohira-Yamasaki M, Toda S, et al.
  An organotypic culture system of Merkel cells using isolated epidermal sheets.
  Br J Dermatol. 2009;161(6):1239-47.
• Aoki S, Takezawa T, Uchihashi K, Sugihara H, Toda S.
  Non-skin mesenchymal cell types support epidermal regeneration in a mesenchymal stem cell or myofibroblast phenotype-independent manner.
  Pathol Int. 2009;59(6):368-75.

2008

• Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, et al.
  A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells.
  Endocrinology. 2008;149(10):4794-8.
• Oishi H, Kagawa Y, Mitsumizo S, Tashiro Y, Kobayashi G, Udo K, et al.
  A fatal case of necrotizing fasciitis due to bacterial translocation of Klebsiella oxytoca.
  J Infect Chemother. 2008;14(1):62-5.
• Kotooka N, Inoue T, Aoki S, Anan M, Komoda H, Node K.
  Prognostic value of pentraxin 3 in patients with chronic heart failure.
  Int J Cardiol. 2008;130(1):19-22.

• Kamochi N, Nakashima M, Aoki S, Uchihashi K, Sugihara H, Toda S, et al.
  Irradiated fibroblast-induced bystander effects on invasive growth of squamous cell carcinoma under cancer-stromal cell interaction.
  Cancer Sci. 2008;99(12):2417-27.

2007

• Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, et al.
  Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro.
  American Journal of Physiology-Gastrointestinal and Liver Physiology. 2007;292(3):G923-G9.

2006

• Aoki S, Sugihara H, Eguchi Y, Watanabe K.
  [The behavior of adipocytes in obesity].
  Nihon Rinsho. 2006;64 Suppl 9:175-9.

2005

• Toda S, Yamada S, Aoki S, Inokuchi A, Sugihara H.
  Air-liquid interface promotes invasive growth of laryngeal squamous cell carcinoma with or without hypoxia.
  Biochem Biophys Res Commun. 2005;326(4):866-72.

2004

• Aoki S, Toda S, Ando T, Sugihara H.
  Bone marrow stromal cells, preadipocytes, and dermal fibroblasts promote epidermal regeneration in their distinctive fashions.
  Mol Biol Cell. 2004;15(10):4647-57.

2003

• Toda S, Aoki S, Suzuki K, Koike E, Ootani A, Watanabe K, et al.
  Thyrocytes, but not C cells, actively undergo growth and folliculogenesis at the periphery of thyroid tissue fragments in three-dimensional collagen gel culture.
  Cell and tissue research. 2003;312(3):281-9.
• Aoki S, Toda S, Sakemi T, Sugihara H.
  Coculture of endothelial cells and mature adipocytes actively promotes immature preadipocyte development in vitro.
  Cell structure and function. 2003;28(1):55-60.

2002

• Tomiyoshi Y, Sakemi T, Aoki S, Miyazono M.
  Different effects of castration and estrogen administration on glomerular injury in spontaneously hyperglycemic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
  Nephron. 2002;92(4):860-7.
• Toda S, Watanabe K, Yokoi F, Matsumura S, Suzuki K, Ootani A, et al.
  A new organotypic culture of thyroid tissue maintains three-dimensional follicles with C cells for a long term.
  Biochemical and biophysical research communications. 2002;294(4):906-11.
• Haraguchi S, Tomiyoshi Y, Aoki S, Sakemi T.
  Nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis in a patient of Waldenstrom’s macroglobulinemia.
  Nephron. 2002;92(2):452-5.

2000

• Yatsunami J, Aoki S, Fukuno Y, Kikuchi Y, Kawashima M, Hayashi S-I.
  Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells.
  International journal of oncology. 2000;17(6):1151-7.
• Tomiyoshi Y, Aoki S, Shimazu K, Ohtsuka Y, Ikeda Y, Yonemitsu N, et al.
  Crescent Formation in Perimembranous-Type Renal Amyloidosis Associated with Multiple Myeloma.
  Nephron. 2000;86(2):253-4.

1999

• Yatsunami J, Fukuno Y, Nagata M, Tsuruta N, Aoki S, Tominaga M, et al.
  Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells.
  Cancer letters. 1999;147(1):17-24.
• Yatsunami J, Fukuno Y, Nagata M, Tominaga M, Aoki S, Tsuruta N, et al.
  Antiangiogenic and antitumor effects of 14-membered ring macrolides on mouse B16 melanoma cells.
  Clinical & experimental metastasis. 1999;17(4):359-65.